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Research News |
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Training Study Questions Fixed Nature of Fluid Intelligence
7 May 2008. For people who struggle with cognitive problems related to schizophrenia or who simply want to hone their ability to think on the fly, a new study may provide a glimmer of hope...
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Prozac and Plasticity—Antidepressant’s Action an Eye Opener
25 April 2008. Selective serotonin reuptake inhibitors such as fluoxetine (better known as Prozac) have always been a bit of a puzzle...
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G Protein-coupled Receptor SREB2/GPR85 Implicated in Schizophrenia
17 April 2008. The hunt for drug targets for schizophrenia takes many forms, and a report outlines an unusual path from genome to potential target...
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Spotlight
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Current Papers—Week of 25 April to 1 May
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Our automated search of PubMed pulled in 127 papers for the week. Remember that you can also display the previous week's papers by selecting them from the dropdown menu at the "Current Papers" field in the Search interface. Please note the following collections of articles:
 Psychiatric Services has a special section devoted to analyses of the CATIE and CUtLASS studies, edited by CATIE coauthor Marvin Swartz of Duke University (see also discussion by SRF members of these two studies, in the context of the more recent EUFEST study)
World Psychiatry has a special debate section, kicked off by Richard Keefe, also of Duke University, on whether cognitive impairment should be included in the diagnostic criteria for schizophrenia.
Clinical EEG and Neuroscience has a special issue devoted to EEG study in schizophrenia (however, the journal is only available in a print edition, so you have to hope your library has a subscription).
Please help us create an online discussion community by picking a paper from the past week, month, or even six months, that really deserves a comment, and then writing that comment today. If you have time, sketch out your impressions in a few paragraphs, a mini-review. If you only have time for the three-sentence "bottom line," that can also be valuable. On to the papers ...
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Which Antipsychotic Drugs Should Be Prescribed?
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Three different large-scale clinical trials have been published in the past three years, each trying to address the thorny question of which antipsychotic drugs are more effective in the "real world." Should first-line treatment be the straight dopamine D2 receptor blockers or the clozapine family members that also target other receptors, particularly serotonergic 5HT2a receptors?
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The American CATIE study (see SRF news story) and the British CUtLASS study (see SRF news story) are now joined by the EUFEST study of antipsychotic drugs in first episode psychosis. Read Victoria Wilcox's summary of the study, as well as the extensive and often critical commentary, and submit your own comment on the data and conclusions of these studies. Read comments by:
Jan Volavka
Peter Buckley
Leslie Citrome
Herbert Meltzer
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NYAS Presents Symposium on DISC1
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The New York Academy of Science and the Biochemical Pharmacology Discussion Group will be hosting an afternoon symposium in New York City on May 27, 2008. Speaking at “DISC1 and the Developmental Hypothesis of Schizophrenia,” will be Akira Sawa of Johns Hopkins, Nicholas Brandon of Wyeth Research, Katherine Burdick of North Shore Long Island Jewish Health System, and Steven Clapcote of the University of Edinburgh. They will present their ideas on the etiology of schizophrenia and how an understanding of DISC1 regulated pathways might relate to the development of new antipsychotic therapies. Pre-registration is required.
Please check the website for more information.
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Welcome to the Schizophrenia Research Forum!
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Welcome to the Schizophrenia Research Forum website—a virtual community for science about schizophrenia and related disorders. Our Mission is to help researchers in their quest for causes, improved treatments, and better understanding of schizophrenia. Read more about ways to browse the site.
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What's New
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Job - Posted 14 May 2008
Senior Postdoctoral Position: Queensland Centre for Mental Health Research, Queensland Department of Health, Queensland Government, Brisbane. |
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Comments - Posted 14 May 2008
Read remarks by Erik Johnsen, Hugo A. Jorgensen about
Kahn RS et al.
NEWS: Study Questions Advantages of Newer Antipsychotics for Early Schizophrenia |
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Comments - Posted 13 May 2008
Read remarks by Ben Pickard about Kidd JM et al.
PAPER: Mapping and sequencing of structural variation from eight human genomes. |
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Job - Posted 13 May 2008
Physician Scientist: Industry, Basel, Switzerland. |
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Job - Posted 12 May 2008
Psychiatric Neuroimaging Research Fellowship: Vanderbilt University School of Medicine, Nashville, Tennessee. |
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Comments - Posted 10 May 2008
Read remarks by Patrick Sullivan
WHAT WE KNOW: Association studies (which identify which form of a particular gene or part of a gene is associated with risk) suggest alleles in a number of promising genes confer risk, including RGS4, DISC1, DTNBP1, NRG1, DAOA and COMT |
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