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Research News
News Brief: NMDA Receptor Antibody False Positives in Schizophrenia
21 May 2015. The hypothesis that some cases of schizophrenia might be autoimmune disorders involving the NMDA receptor, and thus more easily treatable, has received another setback...
ICOSR 2015—A Closer Look at Early Risk Factors for Psychosis
19 May 2015. Researchers gathered for a symposium titled, "At risk from conception: epidemiological evidence for early risk factors for psychosis"...
Cortical Spine Loss Linked With Changes in Dopamine and Behavior
12 May 2015. A mouse model of dendritic spine loss has revealed how changes in cortical synapses cause circuit-level abnormalities...

Journal Club Discussion: Prediction Error and Delusions
The dominant hypothesis of the moment to explain the formation and maintenance of delusions in psychosis is that there is a problem with prediction error: the processing of discrepancies between expected and actual outcomes. In a recent review in Cognitive Neuropsychiatry, Oren Griffiths of the University of New South Wales and colleagues generally support the hypothesis, but call into question some of the
interpretations of studies from Paul Fletcher's group at the University of Cambridge regarding models of faulty prediction error in humans and their underlying neural correlates. Phil Corlett of Yale University and Fletcher wrote a detailed reply, and we would like to expand the discussion of this topic to our readers.

Thanks to Cognitive Neuropsychiatry editor Anthony David and the publisher, Taylor and Francis, we bring you open access to the articles and invite you to comment.
See comment by: Image courtesy of Cognitive Neuropsychiatry
Mountain Air Stimulates Discussion at ICOSR
Pikes Peak
About 1,000 schizophrenia researchers made their way to the Broadmoor Hotel in Colorado Springs, Colorado, for the 15th International Congress on Schizophrenia Research from March 29 to April 1. This year's meeting was one long thank-you to Carol Tamminga and Chuck Schulz, who
founded the meeting and have worked tirelessly to grow it from a few dozen stalwarts into a major biennial event (listen to our podcast interview with them). Carol and Chuck have turned the meeting over to an executive committee led by Jim Meador-Woodruff, and these researchers made appearances throughout the Congress to extol the founders.

Here are the reports from the conference:

  • A Closer Look at Early Risk Factors for Psychosis
  • Neuroimaging: Can It Help Reduce Risk for Schizophrenia?
  • Re-slicing the Pie of Psychosis
  • Is There an Infectious Flame in the Brain in Schizophrenia?
  • Can Neuroimaging Help Reduce Risk for Schizophrenia?
  • Animal Modelers of Psychosis Take Stock
  • Approaches to Prevention in Schizophrenia
  • Patient-Derived Cells For Schizophrenia Research
  • Neuroinflammation, White Matter, and Schizophrenia
  • Boosting Social Cognition in Schizophrenia
  • Higher Fruits From Gene-Gene Interactions?
  • Schizophrenia Researchers Peek at RNA-seq
  • Stress and Glutamate Kick Off Rocky Mountain Congress
  • ACNP Seeks Nominees for 2015 Awards
    The American College of Neuropsychopharmacology is putting out the call for several honorific awards for early to mid-career researchers. Nominations are due June 24, 2015, for the Daniel H. Efron Research Award for outstanding basic research; the Joel Elkes Research Award for clinical research; and the Eva King Killam Research Award for translational research.

    Nominees do not need to be members of the ACNP, but they do need to be younger than 50 years of age for the Efron and Elkes awards, and no more than 12 years out of school for the Killam award. See the full nominating details.
    Welcome to the Schizophrenia Research Forum!
    Welcome to the Schizophrenia Research Forum website—a virtual community for science about schizophrenia and related disorders. Our Mission is to help researchers in their quest for causes, improved treatments, and better understanding of schizophrenia. Read more about ways to browse the site.
    What's New

    Comments - Posted 13 May 2015
    Read remarks by Darryl Eyles
    ONLINE DISCUSSION: Prediction Error: The Genesis of Delusions?
    Comments - Posted 12 May 2015
    Read remarks by Irving Gottesman about Lencz T et al.
    PAPER: Targeting the schizophrenia genome: a fast track strategy from GWAS to clinic.
    Conferences - Posted 10 May 2015
    18th International Neuroscience Winter Conference: 2-6 April 2016, Solden, Austria.
    May 23, 2015
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    SRF will be covering the International Congress on Schizophrenia Research, March 29-April 1, 2015. Look for reports on the sessions.

    See our ongoing Forum Discussion, Prediction Error: The Genesis of Delusions?.
    New Schizophrenia Fact Sheet for Patients and Families

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    An up-to-date collection of all published genetic association studies.
    A community resource created by Jim Koenig, University of Maryland.
    We invite your comments and suggested edits to these facts about schizophrenia.
    Compiled by Angus MacDonald, S. Charles Schulz, and the Minnesota Consensus Group.
    Neural Mechanisms of Real-Time Decisions: Monday, May 18, 2015, 12:00 p.m.

    Rethinking Depression and Its Treatment: Perspectives From Studies of Deep Brain Stimulation: Monday, June 01, 2015, 12:00 p.m.

    Photo-control of Endogenous Ion Channels and Neurotransmitter Receptors in the CNS: Monday, June 15, 2015, 12:00 p.m.

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