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Drugs In Clinical Trials

Important Notice: The Forum does not endorse any medical product or therapy. ALL medications and supplements should be taken ONLY under the supervision of a physician, due to the possibility of side-effects, drug interactions, etc.

Drug: Duloxetine
Clinical Trial ID: NCT00224302
Mode of action: 5-HT and NE transporter inhibitor
Phase: POC Completed
Note: Positive effect as add-on in depressive episodes, negative and general psychopathology with stable positive symptoms effect. No effect when added to clozapine.

Useful Links:

Mico' U, Bruno A, Pandolfo G, Maria Romeo V, Mallamace D, D'Arrigo C, Spina E, Zoccali RA, Muscatello MR. Duloxetine as adjunctive treatment to clozapine in patients with schizophrenia: a randomized, placebo-controlled trial. Int Clin Psychopharmacol . 2011 Nov ; 26(6):303-10. Abstract

Englisch S, Knopf U, Scharnholz B, Kuwilsky A, Deuschle M, Zink M. Duloxetine for major depressive episodes in the course of psychotic disorders: an observational clinical trial. J Psychopharmacol . 2009 Nov 1 ; 23(8):875-82. Abstract

Zink M, Knopf U, Mase E, Kuwilsky A, Deuschle M. Duloxetine treatment of major depressive episodes in the course of psychotic disorders. Pharmacopsychiatry . 2006 May 1 ; 39(3):109-11. Abstract

July 23, 2016
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Check out our upcoming webinar, Studying Psychosis in 22q11 Deletion Syndrome, Thursday, July 28, 2016, 1-2:30 p.m. EDT.

See our recent webinar, The Baby and the Bathwater: Signal and Noise in Psychiatric Neuroimaging.
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