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Drugs In Clinical Trials

Important Notice: The Forum does not endorse any medical product or therapy. ALL medications and supplements should be taken ONLY under the supervision of a physician, due to the possibility of side-effects, drug interactions, etc.

Drug: PF-2545920
Clinical Trial ID: NCT00463372
Mode of action: PDE10
Phase: POC Failed
Company:
Note: Collaboration with Biotie-elbion

Useful Links:

Höfgen N, et al. Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. J Med Chem. 2010 Jun 10;53(11):4399-411. Abstract

H-T Zhang. Phosphodiesterase Targets for Cognitive Dysfunction and Schizophrenia - A New York Academy of Sciences Meeting IDrugs 2010 13:166-168. Abstract

Verhoest PR, Chapin DS, Corman M, Fonseca K, Harms JF, Hou X, Marr ES, Menniti FS, Nelson F, O'Connor R, Pandit J, Proulx-Lafrance C, Schmidt AW, Schmidt CJ, Suiciak JA, Liras S. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem. 2009 Aug 27 ; 52(16):5188-96. Abstract


September 2, 2014
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