Schizophrenia Research Forum: Drugs in Trials
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Drugs in Trials:Histamine
Drug Development status Clinical Trial ID Company or Institution Mechanism Notes
ABT-288 Phase 1   Abbott H3 antagonist Also in development for Alzheimer's disease
BF2.649 Phase 2   University of Texas Southwestern H3 antagonist/inverse agonist Add-on for cognitive disorders, shows effect in narcolepsy
Ciproxifan Preclinical   INSERM H3 antagonist  
GSK189254 Discontinued NCT00387413 GlaxoSmithKline H3 antagonist First indication for narcolepsy; possibly addresses cognitive deficit in schizophrenia
MK0249 Phase 2 NCT00506077 Merck H3-antagonist Add-on for cognition; modest effect in Alzheimer's disease