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Animal Models

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Animal Model: Prenatal Restraint Stress, Rat
Preparation Type: Developmental Preparations
DA-related behavior: Increased novelty induced locomotor activity
Gating: No disruption in PPI
Cognitive behavior: Memory deficits during Y maze and radial arm maze; no apparent deficits in latent inhibition, may or may not show spatial memory defict in water maze task
Molecular/morphological signature: Increased expression of D2-like and NMDA receptors in the frontal cortex and hippocampus; prolonged corticosterone stress response and decreased expression of central corticosteroid receptors (sensitive to cross-fostering); increased basal dopamine and decreased noradrenaline output in the nucleus accumbens; decreased basal noradrenaline output in the prefrontal cortex; apical dendritic atrophy and altered spine density in the hippocampus; decrease neurogenesis in hippocampus
Response to APD: Maternal fluoxetine treatment improves hippocampal neurogenesis and reverses anxiety behaviors in stressed offspring
Citations: Henry C, Kabbaj M, Simon H, Le Moal M, Maccari S. Prenatal stress increases the hypothalamo-pituitary-adrenal axis response in young and adult rats. J Neuroendocrinol . 1994 Jun ; 6(3):341-5. Abstract

Maccari S, Piazza PV, Kabbaj M, Barbazanges A, Simon H, Le Moal M. Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress. J Neurosci . 1995 Jan ; 15(1 Pt 1):110-6. Abstract

Vallée M, Maccari S, Dellu F, Simon H, Le Moal M, Mayo W. Long-term effects of prenatal stress and postnatal handling on age-related glucocorticoid secretion and cognitive performance: a longitudinal study in the rat. Eur J Neurosci . 1999 Aug ; 11(8):2906-16. Abstract

Lemaire V, Koehl M, Le Moal M, Abrous DN. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc Natl Acad Sci U S A . 2000 Sep 26 ; 97(20):11032-7. Abstract

Shalev U, Weiner I. Gender-dependent differences in latent inhibition following prenatal stress and corticosterone administration. Behav Brain Res . 2001 Nov 29 ; 126(1-2):57-63. Abstract

Burton C, Lovic V, Fleming AS. Early adversity alters attention and locomotion in adult Sprague-Dawley rats. Behav Neurosci . 2006 Jun ; 120(3):665-75. Abstract

Maccari S, Morley-Fletcher S. Effects of prenatal restraint stress on the hypothalamus-pituitary-adrenal axis and related behavioural and neurobiological alterations. Psychoneuroendocrinology . 2007 Aug ; 32 Suppl 1():S10-5. Abstract

Berger MA, Barros VG, Sarchi MI, Tarazi FI, Antonelli MC. Long-term effects of prenatal stress on dopamine and glutamate receptors in adult rat brain. Neurochem Res . 2002 Nov ; 27(11):1525-33. Abstract

Silvagni A, Barros VG, Mura C, Antonelli MC, Carboni E. Prenatal restraint stress differentially modifies basal and stimulated dopamine and noradrenaline release in the nucleus accumbens shell: an 'in vivo' microdialysis study in adolescent and young adult rats. Eur J Neurosci . 2008 Aug ; 28(4):744-58. Abstract

Mandyam CD, Crawford EF, Eisch AJ, Rivier CL, Richardson HN. Stress experienced in utero reduces sexual dichotomies in neurogenesis, microenvironment, and cell death in the adult rat hippocampus. Dev Neurobiol . 2008 Apr ; 68(5):575-89. Abstract

Martínez-Téllez RI, Hernández-Torres E, Gamboa C, Flores G. Prenatal stress alters spine density and dendritic length of nucleus accumbens and hippocampus neurons in rat offspring. Synapse . 2009 Sep ; 63(9):794-804. Abstract

Carboni L, Becchi S, Piubelli C, Mallei A, Giambelli R, Razzoli M, Mathé AA, Popoli M, Domenici E. Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression. Prog Neuropsychopharmacol Biol Psychiatry . 2010 Aug 16 ; 34(6):1037-48. Abstract

July 24, 2016
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Check out our upcoming webinar, Studying Psychosis in 22q11 Deletion Syndrome, Thursday, July 28, 2016, 1-2:30 p.m. EDT.

See our recent webinar, The Baby and the Bathwater: Signal and Noise in Psychiatric Neuroimaging.
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