Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
News
Research News
Conference News
Plain English
Forums
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
Interviews
Resources
What We Know
SchizophreniaGene
Animal Models
Drugs in Trials
Research Tools
Grants
Jobs
Conferences
Journals
Community Calendar
General Information
Community
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
Mission
History
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Animal Models

Important Notice: The Forum does not endorse any medical product or therapy. ALL medications and supplements should be taken ONLY under the supervision of a physician, due to the possibility of side-effects, drug interactions, etc.

Animal Model: Prenatal Restraint Stress
Preparation Type: Developmental Preparations
DA-related behavior: Increased novelty induced locomotor activity; enhanced MK-801induced locomotion
Gating: Impaired PPI
Cognitive behavior: Deficits in object recognition memory and contextual fear conditioning
Social behavior: Reduced social interaction
Molecular/morphological signature: Abnormal Purkinje cell growth and dendritic atrophy; glial deficits in the hippocampus (female specific); over-expression of DNMTs mRNA in the frontal cortex; decreased GAD67, reelin, and mGlu2 and mGlu3 receptor protein levels in the frontal cortex; altered neuronal migration
Response to APD: Clozapine reversed deficits in PPI and social interaction; increased locomotive response to MK-801 was attenuated by clozapine; phenotypic rescue with mGluR2/3 agonist or valproic acid
Citations: Behan AT, van den Hove DL, Mueller L, Jetten MJ, Steinbusch HW, Cotter DR, Prickaerts J. Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress. Eur Neuropsychopharmacol . 2011 Jan ; 21(1):71-9. Abstract

Pascual R, Ebner D, Araneda R, Urqueta MJ, Bustamante C. Maternal stress induces long-lasting Purkinje cell developmental impairments in mouse offspring. Eur J Pediatr . 2010 Dec ; 169(12):1517-22. Abstract

Matrisciano F, Tueting P, Dalal I, Kadriu B, Grayson DR, Davis JM, Nicoletti F, Guidotti A. Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice. Neuropharmacology . 2012 Apr 28. Abstract

Matrisciano F, Tueting P, Maccari S, Nicoletti F, Guidotti A. Pharmacological activation of group-II metabotropic glutamate receptors corrects a schizophrenia-like phenotype induced by prenatal stress in mice. Neuropsychopharmacology . 2012 Mar ; 37(4):929-38. Abstract

Stevens HE, Su T, Yanagawa Y, Vaccarino FM. Prenatal stress delays inhibitory neuron progenitor migration in the developing neocortex. Psychoneuroendocrinology . 2013 Apr ; 38(4):509-21. Abstract


December 18, 2014
SRF News
SRF Comments
Text Size
Reset Text Size
Share/Bookmark

See our latest webinar, Cognition and Treatment Resistance in Schizophrenia, held November 10, 2014.

See our last webinar, Research Domain Criteria (RDoC) Applied to Verbal Hallucinations, held May 28, 2014.
Copyright © 2005- 2014 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright