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Animal Models

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Animal Model: Rat Prenatal Immune Challenge: PolyI:C (Delivery Timing Varies)
Preparation Type: Developmental Preparations
DA-related behavior: Increased response to amphetamine (emerges after puberty); in moms that lost or gained little weight offspring showed attenuated hyperactivity in response to MK-801
Gating: Disrupted PPI (possibly sex dependent)
Cognitive behavior: Disrupted latent inhibition (post-puberty); impaired novel object recognition; classical fear conditioning, active avoidance, water maze and discrimination learning appear normal
Molecular/morphological signature: Amphetamine-induced DA release increased; increased hippocampal pyknotic cells
Response to APD: Deficit in latent inhibition was improved by clozapine and haloperidol; altered response to amphetamine was attenuated by adolescent treatment with fluoxetine and aripiprazole
Citations: Zuckerman L, Weiner I. Post-pubertal emergence of disrupted latent inhibition following prenatal immune activation. Psychopharmacology (Berl) . 2003 Sep ; 169(3-4):308-13. Abstract

Zuckerman L, Weiner I. Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring. J Psychiatr Res . 2005 May ; 39(3):311-23. Abstract

Zuckerman L, Rehavi M, Nachman R, Weiner I. Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia. Neuropsychopharmacology . 2003 Oct ; 28(10):1778-89. Abstract

Wolff AR, Bilkey DK. Immune activation during mid-gestation disrupts sensorimotor gating in rat offspring. Behav Brain Res. 2008;190(1):156-9. Abstract

Wolff AR, Cheyne KR, Bilkey DK. Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia. Behav Brain Res. 2011;225(1):382-7. Abstract

Vorhees CV, Graham DL, Braun AA, Schaefer TL, Skelton MR, Richtand NM, Williams MT. Prenatal immune challenge in rats: altered responses to dopaminergic and glutamatergic agents, prepulse inhibition of acoustic startle, and reduced route-based learning as a function of maternal body weight gain after prenatal exposure to poly IC. Synapse. 2012;66(8):725-37. Abstract

Richtand NM, Ahlbrand R, Horn P, Tambyraja R, Grainger M, Bronson SL, McNamara RK. Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response. Physiol Behav. 2012;106(2):171-7. Abstract


August 22, 2014
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