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Animal Models

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Animal Model: Snap 25 Heterozygous KO/BDR and Prenatal Stress
Preparation Type: Gene-Environmental Interaction Preparations
DA-related behavior: No interaction on open field activity
Gating: PNS/Bdr mice had increased deficit in PPI
Cognitive behavior: No interaction effect on short-term memory in Y maze task; no effect on novel object recognition
Social behavior: Decreased social interaction and impaired social novelty preference in PNS/Bdr mice
Response to APD: Clozapine improved PPI deficit in PDS/Bdr
Citations: Oliver PL, Davies KE. Interaction between environmental and genetic factors modulates schizophrenic endophenotypes in the Snap-25 mouse mutant blind-drunk. Hum Mol Genet. 2009 Dec 1;18(23):4576-89. Abstract

November 27, 2015
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