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Animal Models

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Animal Model: Nurr1 Heterozygous KO and PolyI:C Exposure
Preparation Type: Gene-Environmental Interaction Preparations
DA-related behavior: Hyperactive in open field
Gating: Increased PPI deficit
Cognitive behavior: Impaired attentional shifting; no interaction effect on spatial working memory
Molecular/morphological signature: Decreased accumbal D2 receptors; decreased PFC tyrosine hydroxylase expression; increased PFC COMT expression
Citations: Vuillermot S, Joodmardi E, Perlmann T, ?gren SO, Feldon J, Meyer U. Prenatal immune activation interacts with genetic Nurr1 deficiency in the development of attentional impairments. J Neurosci. 2012 Jan 11;32(2):436-51. Abstract

Vuillermot S, Feldon J, Meyer U. Nurr1 is not essential for the development of prepulse inhibition deficits induced by prenatal immune activation. Brain Behav Immun. 2011 Oct;25(7):1316-21. Abstract

July 26, 2016
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Check out our upcoming webinar, Studying Psychosis in 22q11 Deletion Syndrome, Thursday, July 28, 2016, 1-2:30 p.m. EDT.

See our recent webinar, The Baby and the Bathwater: Signal and Noise in Psychiatric Neuroimaging.
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