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Animal Models

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Animal Model: mhDISC1 and polyI:C exposure
Preparation Type: Gene-Environmental Interaction Preparations
DA-related behavior: Increased activity in periphery of open field
Gating: No PPI deficit
Cognitive behavior: No interaction effects on novel object recognition; sptial working memory in Y maze, or spatial learning in water maze
Social behavior: Lack of preference for sniffing mouse vs inanimate object; normal social novelty preference
Molecular/morphological signature: PolyI:C exposure on gestation day 9; genotype affected cytokine upregulation in response to immune challenge; reduced hippocampal dendritic spine density; attenuated corticosterone response to restraint stress


September 1, 2014
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