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product or therapy. ALL medications and supplements
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due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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mhDISC1 and polyI:C exposure
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Preparation Type:
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Gene-Environmental Interaction Preparations
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DA-related behavior:
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Increased activity in periphery of open field
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Gating:
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No PPI deficit
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Cognitive behavior:
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No interaction effects on novel object recognition; sptial
working memory in Y maze, or spatial learning in water maze
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Social behavior:
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Lack of preference for sniffing mouse vs inanimate object;
normal social novelty preference
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Molecular/morphological signature:
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PolyI:C exposure on gestation day 9; genotype affected
cytokine upregulation in response to immune challenge;
reduced hippocampal dendritic spine density; attenuated
corticosterone response to restraint stress
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