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Animal Model:
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DN-DISC1 and PolyI:C exposure
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Preparation Type:
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Gene-Environmental Interaction Preparations
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DA-related behavior:
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Hypersensitive to MK-801
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Cognitive behavior:
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Impaired object recognition; impaired fear conditioning
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Social behavior:
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Decreased social interaction; impaired social recognition
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Molecular/morphological signature:
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PolyI :C exposure on postnatal days 2-6; Decreased GABAergic
interneurons in mPFC
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Response to APD:
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Clozapine normalized sensitivity to MK-801 as well as
cognitive impairment; did not improve social deficits
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