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Animal Models

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Animal Model: COMT KO and Chronic THC Exposure
Preparation Type: Gene-Environmental Interaction Preparations
DA-related behavior: Increased hyperactivity in open field in males
Cognitive behavior: No interaction effect on object recognition; increased spatial working memory impairment
Social behavior: No interaction effects on social interaction or social novelty preference
Citations: O'Tuathaigh CM, Hryniewiecka M, Behan A, Tighe O, Coughlan C, Desbonnet L, Cannon M, Karayiorgou M, Gogos JA, Cotter DR, Waddington JL. Chronic adolescent exposure to Δ-9-tetrahydrocannabinol in COMT mutant mice: impact on psychosis- related and other phenotypes. Neuropsychopharmacology. 2010 Oct;35(11):2262-73. Abstract

O'Tuathaigh CM, Clarke G, Walsh J, Desbonnet L, Petit E, O'Leary C, Tighe O, Clarke N, Karayiorgou M, Gogos JA, Dinan TG, Cryan JF, Waddington JL. Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes.Int J Neuropsychopharmacol. 2012 Oct;15(9):1331-42. Abstract


November 27, 2014
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