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Animal Models

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Animal Model: Complexin II KO and Parietal Neurotrauma
Preparation Type: Gene-Environmental Interaction Preparations
DA-related behavior: No interaction effect on open field behavior
Gating: No interaction effect on PPI; increase in startle amplitude
Cognitive behavior: Spatial memory deficit
Social behavior: No interaction effect on social interaction
Molecular/morphological signature: Reduced hippocampal volume
Citations: Radyushkin K, El-Kordi A, Boretius S, Castaneda S, Ronnenberg A, Reim K, Bickeb?ller H, Frahm J, Brose N, Ehrenreich H. Complexin2 null mutation requires a 'second hit' for induction of phenotypic changes relevant to schizophrenia. Genes Brain Behav. 2010 Aug;9(6):592-602. Abstract

November 30, 2015
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