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Animal Model:
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Chromosome 22q11.2 Deletion Model-Df(16)A Mice
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Hyperactive in novel environment
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Gating:
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PPI deficit
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Cognitive behavior:
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Impaired fear conditioning; spatial learning deficit
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Molecular/morphological signature:
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Reduced dendritic spines in HPC; reduced
hippocampal-prefrontal synchrony
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Citations:
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Paylor R, McIlwain KL, McAninch R, Nellis A, Yuva-Paylor LA,
Baldini A, Lindsay EA. Mice deleted for the
DiGeorge/velocardiofacial syndrome region show abnormal
sensorimotor gating and learning and memory impairments. Hum
Mol Genet . 2001 Nov 1 ; 10(23):2645-50. Abstract
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