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Animal Models

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Animal Model: Chromosome 22q11.2 Deletion Model-Df(16)A
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in novel environment
Gating: PPI deficit
Cognitive behavior: Impaired fear conditioning; spatial learning deficit
Molecular/morphological signature: Reduced dendritic spines in HPC, reduced hippocampal-prefrontal synchrony, Dgcr8 haploinsufficiency, disruption of synaptic transmission at thalamocortical glutamatergic projection in the auditory cortex
Response to APD: Thalamocortical projections sensitive to antipsychotics
Citations: Paylor R, McIlwain KL, McAninch R, Nellis A, Yuva-Paylor LA, Baldini A, Lindsay EA. Mice deleted for the DiGeorge/velocardiofacial syndrome region show abnormal sensorimotor gating and learning and memory impairments. Hum Mol Genet . 2001 Nov 1 ; 10(23):2645-50. Abstract

Sigurdsson T, Stark KL, Karayiorgou M, Gogos JA, Gordon JA. Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia. Nature. 2010 Apr 1;464(7289):763-7. Abstract

Stark KL, Xu B, Bagchi A, Lai WS, Liu H, Hsu R, Wan X, Pavlidis P, Mills AA, Karayiorgou M, Gogos JA. Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model. Nat Genet. 2008 Jun;40(6):751-60. Abstract

Mukai J, et al. Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion. Nature Neurosci. 2008;11:1302?1310. Abstract


December 21, 2014
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