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Animal Models

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Animal Model: Chromosome 22q11.2 Deletion Model-Df(16)A
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in novel environment
Gating: PPI deficit
Cognitive behavior: Impaired fear conditioning; spatial learning deficit
Molecular/morphological signature: Reduced dendritic spines in HPC; reduced hippocampal-prefrontal synchrony
Citations: Paylor R, McIlwain KL, McAninch R, Nellis A, Yuva-Paylor LA, Baldini A, Lindsay EA. Mice deleted for the DiGeorge/velocardiofacial syndrome region show abnormal sensorimotor gating and learning and memory impairments. Hum Mol Genet . 2001 Nov 1 ; 10(23):2645-50. Abstract


November 25, 2014
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