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product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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Transient DISC1 Knockdown in PFC in utero
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Normal spontaneous locomotion; hypersensitive to methamphetamine
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Gating:
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PPI deficits in adults but not juveniles
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Cognitive behavior:
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Impairment in novel object recognition test
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Molecular/morphological signature:
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Reduced dopamine concentration in PFC; Reduced
parvalbumin-positive interneurons in PFC
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Response to APD:
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PPI deficits normalized by clozapine; impairment in novel
object recogntion test normalized by clozapine
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