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Animal Models

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Animal Model: DISC1 Transient Knockdown in PFC (In Utero)
Preparation Type: Genetic Preparations
DA-related behavior: Normal spontaneous locomotion; hypersensitive to methamphetamine
Gating: PPI deficits in adults but not juveniles
Cognitive behavior: Impairment in novel object recognition test
Molecular/morphological signature: Reduced dopamine concentration in PFC; Reduced parvalbumin-positive interneurons in PFC
Response to APD: PPI deficits normalized by clozapine; impairment in novel object recogntion test normalized by clozapine
Citations: Niwa M, Kamiya A, Murai R, Kubo K, Gruber AJ, Tomita K, Lu L, Tomisato S, Jaaro-Peled H, Seshadri S, Hiyama H, Huang B, Kohda K, Noda Y, O'Donnell P, Nakajima K, Sawa A, Nabeshima T. Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron. 2010 Feb 25;65(4):480-9. Abstract

December 1, 2015
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