 |
|
|
Important Notice: The Forum does not endorse any medical
product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
|
Animal Model:
|
DISC1 L100P Missense Mutation
|
|
Preparation Type:
|
Genetic Preparations
|
|
DA-related behavior:
|
Increased locomotor activity; enhanced response to amphetamine
|
|
Gating:
|
Disrupted PPI; Decreased startle amplitude
|
|
Cognitive behavior:
|
Working memory impaired in T-maze; normal spatial learning
in water maze
|
|
Molecular/morphological signature:
|
Reduced brain volume; reduced dendritic spine density;
increased striatal dopamine receptors
|
|
Response to APD:
|
Clozapine and haloperidol reversed PPI deficit; genetic
inactivation of GSK-3alpha improves PPI, hyperactivity and
dendritic spine abnormalities
|
|
|
|
|
|
Text Size 
See our most recent Schizophrenia Bulletin theme Webinar: