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Animal Models

Important Notice: The Forum does not endorse any medical product or therapy. ALL medications and supplements should be taken ONLY under the supervision of a physician, due to the possibility of side-effects, drug interactions, etc.

Animal Model: DISC1 Dominant-Negative Transgenic Mice
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in open field
Gating: No PPI deficit
Cognitive behavior: No impairment in working memory in T-maze or spatial learning in water maze
Social behavior: Impaired social interaction
Molecular/morphological signature: Decreased cortical parvalbumin-containing cells


May 19, 2013
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See our most recent Schizophrenia Bulletin theme Webinar: Taking Stock of Glutamate in Schizophrenia, held 5 February 2013.

Check out our Schizophrenia Bulletin theme Webinar: Neurotropic Infectious Agents and Cognitive Impairment in Schizophrenia, held 13 November 2012.
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