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due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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Combined Grin D481N/K483Q Point Mutation
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Nonhabituating hyperactivity
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Gating:
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Increased startle response, no PPI deficit
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Cognitive behavior:
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Impaired spatial learning
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Social behavior:
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Impaired nest building
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Molecular/morphological signature:
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Reduced NMDAR glycine affinity; reduced LTP in hippocampus
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Response to APD:
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Clozapine and haloperidol did not reduce hyperactivity
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