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product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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Grin1D481N NR1 Point Mutation
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Preparation Type:
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Genetic Preparations
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Gating:
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Persistent latent inhibition; no PPI deficit; increased
startle reactivity
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Cognitive behavior:
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Spatial recognition impairments
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Social behavior:
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Social approach deficits
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Molecular/morphological signature:
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Reduced NMDAR glycine affinity; reduced LTP in hippocampus
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Response to APD:
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Phenotype reversed by D-serine treatment as well as D-amino
acid oxidase gene deletion
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