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Animal Models

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Animal Model: Sp4 Hypomorphic Mouse
Preparation Type: Genetic Preparations
Gating: PPI deficit
Cognitive behavior: Impaired spatial learning; impaired LTP
Molecular/morphological signature: Hippocampal vacuolization; abnormal development of dentate gyrus; reduced levels of NMDA-NR1 but not NR2A or NR2B
Citations: Zhou X, Qyang Y, Kelsoe JR, Masliah E, Geyer MA. Impaired postnatal development of hippocampal dentate gyrus in Sp4 null mutant mice. Genes Brain Behav. 2007 Apr;6(3):269-76. Abstract

Zhou X, Long JM, Geyer MA, Masliah E, Kelsoe JR, Wynshaw-Boris A, Chien KR. Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization. Mol Psychiatry. 2005 Apr;10(4):393-406. Abstract

Zhou X, Nie Z, Roberts A, Zhang D, Sebat J, Malhotra D, Kelsoe JR, Geyer MA. Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders. Hum Mol Genet. 2010 Oct 1;19(19):3797-805. Abstract


November 27, 2014
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