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Animal Models

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Animal Model: Sp4 Hypomorphic Mice
Preparation Type: Genetic Preparations
Gating: PPI deficit
Cognitive behavior: Impaired spatial learning; impaired LTP
Molecular/morphological signature: Hippocampal vacuolization; abnormal development of dentate gyrus; reduced levels of NMDA-NR1 but not NR2A or NR2B


May 24, 2013
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See our most recent Schizophrenia Bulletin theme Webinar: Taking Stock of Glutamate in Schizophrenia, held 5 February 2013.

Check out our Schizophrenia Bulletin theme Webinar: Neurotropic Infectious Agents and Cognitive Impairment in Schizophrenia, held 13 November 2012.
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