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Animal Models

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Animal Model: Urokinase Plasminogen Activator Receptor KO (Plaur)
Preparation Type: Genetic Preparations
Cognitive behavior: Impaired reversal learning
Molecular/morphological signature: Reduced parvalbumin-positive interneurons in anterior cingulate and orbitofrontal cortex; reduced levels of HGF/SF
Response to APD: Postnatal supplementation with HGF/SF normalizes reversal learning impairment
Citations: Powell EM, Campbell DB, Stanwood GD, Davis C, Noebels JL, Levitt P. Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction. J Neurosci. 2003 Jan 15;23(2):622-31. Abstract

Eagleson KL, Bonnin A, Levitt P. Region- and age-specific deficits in gamma-aminobutyric acidergic neuron development in the telencephalon of the uPAR(-/-) mouse. J Comp Neurol. 2005 Sep 5;489(4):449-66. Abstract

Bissonette GB, Bae MH, Suresh T, Jaffe DE, Powell EM. Astrocyte-mediated hepatocyte growth factor/scatter factor supplementation restores GABAergic interneurons and corrects reversal learning deficits in mice. J Neurosci. 2010 Feb 24;30(8):2918-23. Abstract


December 19, 2014
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