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Animal Models

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Animal Model: PACAP KO Mouse
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in open field
Gating: PPI deficit
Social behavior: Reduced social interaction
Response to APD: Hyperactivity reduced with risperidone; PPI deficit reversed by risperidone; social interaction deficit and hyperactivity reduced when animals raised in enriched environment
Citations: Ishihama T, Ago Y, Shintani N, Hashimoto H, Baba A, Takuma K, Matsuda T. Environmental factors during early developmental period influence psychobehavioral abnormalities in adult PACAP-deficient mice. Behav Brain Res. 2010 Jun 19;209(2):274-80. Abstract

Hashimoto R, Hashimoto H, Shintani N, Chiba S, Hattori S, Okada T, Nakajima M, Tanaka K, Kawagishi N, Nemoto K, Mori T, Ohnishi T, Noguchi H, Hori H, Suzuki T, Iwata N, Ozaki N, Nakabayashi T, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Kunugi H, Baba A. Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia. Mol Psychiatry. 2007 Nov;12(11):1026-32. Abstract

Fujii H, Ishihama T, Ago Y, Shintani N, Kakuda M, Hashimoto H, Baba A, Matsuda T. Methamphetamine-induced hyperactivity and behavioral sensitization in PACAP deficient mice. Peptides. 2007 Sep;28(9):1674-9. Abstract

Tanaka K, Shintani N, Hashimoto H, Kawagishi N, Ago Y, Matsuda T, Hashimoto R, Kunugi H, Yamamoto A, Kawaguchi C, Shimada T, Baba A. Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice. J Neurosci. 2006 May 10;26(19):5091-7. Abstract

Hashimoto H, Hashimoto R, Shintani N, Tanaka K, Yamamoto A, Hatanaka M, Guo X, Morita Y, Tanida M, Nagai K, Takeda M, Baba A. Depression-like behavior in the forced swimming test in PACAP-deficient mice: amelioration by the atypical antipsychotic risperidone. J Neurochem. 2009 Jul;110(2):595-602. Abstract


November 27, 2014
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See our latest webinar, Cognition and Treatment Resistance in Schizophrenia, held November 10, 2014.

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