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Animal Models

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Animal Model: Neurotensin 2 Receptor KO
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in open field (Liang; – not found by Feifel)
Gating: Enhanced PPI in males
Molecular/morphological signature: Increased striatal dopamine
Citations: Feifel D, Pang Z, Shilling PD, Melendez G, Schreiber R, Button D. Effects of neurotensin-2 receptor deletion on sensorimotor gating and locomotor activity. Behav Brain Res. 2010 Oct 15;212(2):174-8. doi: 10.1016/j.bbr.2010.04.014. Epub 2010 Apr 21. Erratum in: Behav Brain Res. 2011 Mar 1;217(2):486. Abstract

Li Z, Liang Y, Boules M, Gordillo A, Richelson E. Effect of amphetamine on extracellular concentrations of amino acids in striatum in neurotensin subtype 1 and 2 receptor null mice: a possible interaction between neurotensin receptors and amino acid systems for study of schizophrenia. Neuropharmacology. 2010 Jun;58(7):1174-8. Abstract

November 28, 2015
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