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Animal Models

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Animal Model: Neurotensin 1 Receptor KO
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in open field; no effect of PCP on locomotor activity; enhanced hyperactivity in response to amphetamine
Gating: No PPI deficit (Feifel)
Molecular/morphological signature: Decreased glutamate and NMDA-2A subunit concentration; increased striatal dopamine
Citations: Feifel D, Pang Z, Shilling PD, Melendez G, Schreiber R, Button D. Sensorimotor gating in neurotensin-1 receptor null mice. Neuropharmacology. 2010 Jan;58(1):173-8. Abstract

Li Z, Liang Y, Boules M, Gordillo A, Richelson E. Effect of amphetamine on extracellular concentrations of amino acids in striatum in neurotensin subtype 1 and 2 receptor null mice: a possible interaction between neurotensin receptors and amino acid systems for study of schizophrenia. Neuropharmacology. 2010 Jun;58(7):1174-8. Abstract

Liang Y, Boules M, Li Z, Williams K, Miura T, Oliveros A, Richelson E. Hyperactivity of the dopaminergic system in NTS1 and NTS2 null mice. Neuropharmacology. 2010 Jun;58(8):1199-205. Abstract


December 21, 2014
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