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Animal Models

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Animal Model: Glutamate-Cysteine-Ligase Modifier (GCLM) KO
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in novel setting (Kulak; not found by Cole); potentiated locomotor response to amphetamine
Gating: No PPI deficits (Cole); mild PPI deficit (Kulak)
Cognitive behavior: Normal spatial working memory and spatial learning
Social behavior: Abnormal social preference (Kulak)
Molecular/morphological signature: Glutathione deficiency
Citations: Kulak A, Cuenod M, Do KQ. Behavioral phenotyping of glutathione-deficient mice: relevance to schizophrenia and bipolar disorder. Behav Brain Res. 2012 Jan 15;226(2):563-70. Abstract

Chen Y, Curran CP, Nebert DW, Patel KV, Williams MT, Vorhees CV. Effect of chronic glutathione deficiency on the behavioral phenotype of Gclm-/- knockout mice. Neurotoxicol Teratol. 2012 Jul;34(4):450-7. Abstract

Cole TB, Giordano G, Co AL, Mohar I, Kavanagh TJ, Costa LG. Behavioral Characterization of GCLM-Knockout Mice, a Model for Enhanced Susceptibility to Oxidative Stress. J Toxicol. 2011;2011:157687. Abstract


December 20, 2014
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