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Important Notice: The Forum does not endorse any medical
product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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Glutamate-Cysteine-Ligase Modifier (GCLM) KO Mice
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Hyperactive in novel setting (Kulak; not found by Cole);
potentiated locomotor response to amphetamine
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Gating:
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No PPI deficits (Cole); mild PPI deficit (Kulak)
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Cognitive behavior:
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Normal spatial working memory and spatial learning
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Social behavior:
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Abnormal social preference (Kulak)
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Molecular/morphological signature:
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Glutathione deficiency
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