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Animal Models

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Animal Model: FGFR1 Catecholaminergic Neuron Targeted Knockout
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in open field
Gating: Increased startle response; PPI deficits
Social behavior: Decreased social interaction
Molecular/morphological signature: Increased striatal dopamine metabolites
Response to APD: PPI deficit reversed with flupenthixol, quetiapine and clozapine; clozapine did not reduce hyperactivity
Citations: Klejbor, A. Kucinski, S.R. Wersinger, T. Corso, J.H. Spodnik, J. Dziewiatkowski, J. Morys, R.A. Hesse, K.C. Rice, R. Miletich, E.K. Stachowiak, M.K. Stachowiak. Serotonergic hyperinnervation and effective serotonin blockade in an FGF receptor developmental model of psychosis. Schizophr. Res., 113 (2?3) (2009), pp. 308?321. Abstract

Klejbor I, Myers JM, Hausknecht K, Corso TD, Gambino AS, Morys J, Maher PA, Hard R, Richards J, Stachowiak EK, Stachowiak MK. Fibroblast growth factor receptor signaling affects development and function of dopamine neurons - inhibition results in a schizophrenia-like syndrome in transgenic mice. J Neurochem. 2006 Jun;97(5):1243-58. Abstract

July 30, 2016
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