Schizophrenia Research Forum - A Catalyst for Creative Thinking
Home Profile Membership/Get Newsletter Log In Contact Us
 For Patients & Families
What's New
Recent Updates
SRF Papers
Current Papers
Search All Papers
Search Comments
Research News
Conference News
Plain English
Current Hypotheses
Idea Lab
Online Discussions
Virtual Conferences
What We Know
Animal Models
Drugs in Trials
Research Tools
Community Calendar
General Information
Member Directory
Researcher Profiles
Institutes and Labs
About the Site
SRF Team
Advisory Board
Support Us
How to Cite
Fan (E)Mail
The Schizophrenia Research Forum web site is sponsored by the Brain and Behavior Research Foundation and was created with funding from the U.S. National Institute of Mental Health.
Animal Models

Important Notice: The Forum does not endorse any medical product or therapy. ALL medications and supplements should be taken ONLY under the supervision of a physician, due to the possibility of side-effects, drug interactions, etc.

Animal Model: FGFR1 Catecholaminergic Neuron Targeted Knockout
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in open field
Gating: Increased startle response; PPI deficits
Social behavior: Decreased social interaction
Molecular/morphological signature: Increased striatal dopamine metabolites
Response to APD: PPI deficit reversed with flupenthixol, quetiapine and clozapine; clozapine did not reduce hyperactivity
Citations: Klejbor, A. Kucinski, S.R. Wersinger, T. Corso, J.H. Spodnik, J. Dziewiatkowski, J. Morys, R.A. Hesse, K.C. Rice, R. Miletich, E.K. Stachowiak, M.K. Stachowiak. Serotonergic hyperinnervation and effective serotonin blockade in an FGF receptor developmental model of psychosis. Schizophr. Res., 113 (2?3) (2009), pp. 308?321. Abstract

Klejbor I, Myers JM, Hausknecht K, Corso TD, Gambino AS, Morys J, Maher PA, Hard R, Richards J, Stachowiak EK, Stachowiak MK. Fibroblast growth factor receptor signaling affects development and function of dopamine neurons - inhibition results in a schizophrenia-like syndrome in transgenic mice. J Neurochem. 2006 Jun;97(5):1243-58. Abstract

December 1, 2015
SRF News
SRF Comments
Text Size
Reset Text Size

Check out our most recent webinar, How Can Schizotypy Inform Schizophrenia Research?.
Copyright © 2005- 2015 Schizophrenia Research Forum Privacy Policy Disclaimer Disclosure Copyright