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Animal Models

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Animal Model: NCAM-EC Overexpressing Mouse
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in open field; enhanced response to amphetamine and MK-801
Gating: PPI deficit
Cognitive behavior: Decreased LTP in PFC, normal LTP in HPC; impaired working memory
Social behavior: Normal sociability
Molecular/morphological signature: Abnormal GABAergic interneurons
Response to APD: PPI deficit reversed by clozapine but not haloperidol
Citations: Pillai-Nair N, Panicker AK, Rodriguiz RM, Gilmore KL, Demyanenko GP, Huang JZ, Wetsel WC, Maness PF. Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior. J Neurosci. 2005 May 4;25(18):4659-71. Abstract

Brennaman LH, Maness PF. Developmental regulation of GABAergic interneuron branching and synaptic development in the prefrontal cortex by soluble neural cell adhesion molecule. Mol Cell Neurosci. 2008 Apr;37(4):781-93. Abstract

Brennaman LH, Kochlamazashvili G, Stoenica L, Nonneman RJ, Moy SS, Schachner M, Dityatev A, Maness PF. Transgenic mice overexpressing the extracellular domain of NCAM are impaired in working memory and cortical plasticity. Neurobiol Dis. 2011 Aug;43(2):372-8. Abstract


November 28, 2014
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