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Animal Models

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Animal Model: NCAM-EC overexpressing mice
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in open field; enhanced response to amphetamine and MK-801
Gating: PPI deficit
Cognitive behavior: Decreased LTP in PFC, normal LTP in HPC; impaired working memory
Social behavior: Normal sociability
Molecular/morphological signature: Abnormal GABAergic interneurons
Response to APD: PPI deficit reversed by clozapine but not haloperidol


May 22, 2013
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See our most recent Schizophrenia Bulletin theme Webinar: Taking Stock of Glutamate in Schizophrenia, held 5 February 2013.

Check out our Schizophrenia Bulletin theme Webinar: Neurotropic Infectious Agents and Cognitive Impairment in Schizophrenia, held 13 November 2012.
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