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Animal Model:
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Homer1 KO
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Hypoactive; enhanced locomotor behavior to MK-801 and
methamphetamine
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Gating:
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Disrupted PPI (Szumlinski; not found by Jaubert)
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Cognitive behavior:
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Decreased radial arm maze performance
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Social behavior:
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Increased social interaction; increased aggression in
heterozygotes; impaired nest-building
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Molecular/morphological signature:
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Decreased glutamate release in PFC following cocaine Rx
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Citations:
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Szumlinski KK, Lominac KD, Kleschen MJ, Oleson EB, Dehoff
MH, Schwarz MK, Schwartz MK, Seeburg PH, Seeberg PH, Worley
PF, Kalivas PW. Behavioral and neurochemical phenotyping of
Homer1 mutant mice: possible relevance to schizophrenia.
Genes Brain Behav . 2005 Jul 1 ; 4(5):273-88.
Abstract
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