 |
|
|
Important Notice: The Forum does not endorse any medical
product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
|
Animal Model:
|
Cannabinoid receptor 2 KO
|
|
Preparation Type:
|
Genetic Preparations
|
|
DA-related behavior:
|
Hypoactive in open field; enhanced hyperactivity in response
to cocaine
|
|
Gating:
|
PPI deficit
|
|
Cognitive behavior:
|
Impaired memory consolidation
|
|
Response to APD:
|
PPI deficit improved by risperidone
|
|
Citations:
|
Szumlinski KK, Lominac KD, Kleschen MJ, Oleson EB, Dehoff
MH, Schwarz MK, Schwartz MK, Seeburg PH, Seeberg PH, Worley
PF, Kalivas PW. Behavioral and neurochemical phenotyping of
Homer1 mutant mice: possible relevance to schizophrenia.
Genes Brain Behav . 2005 Jul 1 ; 4(5):273-88. Abstract
|
|
|
|
|
|
Text Size 
See our most recent Schizophrenia Bulletin theme Webinar: