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Animal Model:
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AKT1 KO Mice
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Normal activity in open field
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Gating:
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No baseline PPI in males, baseline PPI deficit in females
(Chen; Emamian did not find PPI deficit in either sex at
baseline); PPI deficit caused by amphetamine
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Cognitive behavior:
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No impairment in spatial learning
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Response to APD:
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Antipsychotics did not normalize PPI in females, but GSK
inhibitors did
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Citations:
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Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA.
Convergent evidence for impaired AKT1-GSK3beta signaling in
schizophrenia. Nat Genet . 2004 Feb ; 36(2):131-7. Abstract
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