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Animal Models

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Animal Model: Nurr1 Heterozygous KO
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in novel environment and also after amphetamine; enhanced response to MK-801
Gating: Disrupted PPI in males but not females
Cognitive behavior: Decreased emotional memory; intact spatial memory
Social behavior: No social interaction deficit
Molecular/morphological signature: Reduced DA turnover in striatum; Increased DA turnover in PFC
Response to APD: Haloperidol reverses spontaneous hyperactivity
Citations: Eells JB, Misler JA, Nikodem VM. Early postnatal isolation reduces dopamine levels, elevates dopamine turnoverand specifically disrupts prepulse inhibition in Nurr1-null heterozygous mice. Neuroscience. 2006 Jul 21;140(4):1117-26. Abstract

Eells JB, Misler JA, Nikodem VM. Reduced tyrosine hydroxylase and GTP cyclohydrolase mRNA expression, tyrosine hydroxylase activity, and associated neurochemical alterations in Nurr1-nullheterozygous mice. Brain Res Bull. 2006 Jun 30;70(2):186-95. Abstract

Eells JB, Lipska BK, Yeung SK, Misler JA, Nikodem VM. Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity. Behav Brain Res. 2002 Oct 17;136(1):267-75. Abstract

Rojas P, Joodmardi E, Hong Y, Perlmann T, Ogren SO. Adult mice with reduced Nurr1 expression: an animal model for schizophrenia. Mol Psychiatry. 2007 Aug;12(8):756-66. Abstract


December 20, 2014
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