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Animal Models

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Animal Model: Nurr1 Heterozygous KO
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in novel environment and also after amphetamine; enhanced response to MK-801
Gating: Disrupted PPI in males but not females
Cognitive behavior: Decreased emotional memory; intact spatial memory
Social behavior: No social interaction deficit
Molecular/morphological signature: Reduced DA turnover in striatum; Increased DA turnover in PFC
Response to APD: Haloperidol reverses spontaneous hyperactivity


September 30, 2014
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