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product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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Brattleboro (vasopressin-deficient) rats
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Hyperactive in novel setting
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Gating:
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Increased acoustic startle and decreased PPI
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Social behavior:
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Impaired social discrimination
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Molecular/morphological signature:
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Point mutation in gene for vasopressin; decreased dopamine
concentration in frontal cortex
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Response to APD:
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PPI deficit reversed by acute clozapine and risperidone;
chronic but not acute haloperidol reverses deficit
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