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Animal Models

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Animal Model: Brattleboro (Vasopressin-Deficient) Rat
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in novel setting
Gating: Increased acoustic startle and decreased PPI
Social behavior: Impaired social discrimination
Molecular/morphological signature: Point mutation in gene for vasopressin; decreased dopamine concentration in frontal cortex
Response to APD: PPI deficit reversed by acute clozapine and risperidone; chronic but not acute haloperidol reverses deficit
Citations: Feifel D, Mexal S, Melendez G, Liu PY, Goldenberg JR, Shilling PD. The brattleboro rat displays a natural deficit in social discrimination that is restored by clozapine and a neurotensin analog. Neuropsychopharmacology. 2009 Jul;34(8):2011-8. Abstract

Schank JC. Early locomotor and social effects in vasopressin deficient neonatal rats. Behav Brain Res. 2009 Jan 30;197(1):166-77. Abstract

Feifel D, Melendez G, Priebe K, Shilling PD. The effects of chronic administration of established and putative antipsychotics on natural prepulse inhibition deficits in Brattleboro rats. Behav Brain Res. 2007 Aug 6;181(2):278-86. Abstract

Feifel D, Priebe K. Vasopressin-deficient rats exhibit sensorimotor gating deficits that are reversed by subchronic haloperidol. Biol Psychiatry. 2001 Sep 15;50(6):425-33. Abstract

Feenstra MG, Snijdewint FG, Van Galen H, Boer GJ. Widespread alterations in central noradrenaline, dopamine, and serotonin systems in the Brattleboro rat not related to the local absence of vasopressin. Neurochem Res. 1990 Mar;15(3):283-8. Abstract

July 29, 2016
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