 |
|
|
Important Notice: The Forum does not endorse any medical
product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
|
Animal Model:
|
YWHAE Heterozygous KO
|
|
Preparation Type:
|
Genetic Preparations
|
|
DA-related behavior:
|
Normal activity in open field
|
|
Gating:
|
No PPI deficits
|
|
Cognitive behavior:
|
Mild deficit in spatial working memory, no impairment in
reversal learning
|
|
Social behavior:
|
Normal social interaction
|
|
Molecular/morphological signature:
|
50% reduction of 14-3-3epsilon protein expression
|
|
Citations:
|
Ikeda M, Hikita T, Taya S, Uraguchi-Asaki J, Toyo-oka K,
Wynshaw-Boris A, Ujike H, Inada T, Takao K, Miyakawa T,
Ozaki N, Kaibuchi K, Iwata N. Identification of YWHAE, a
gene encoding 14-3-3epsilon, as a possible susceptibility
gene for schizophrenia. Hum Mol Genet . 2008 Oct 15 ;
17(20):3212-22. Abstract
|
|
|
|
|
|
Text Size 
See our most recent Schizophrenia Bulletin theme Webinar: