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Animal Models

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Animal Model: Prefrontal Cortical Lesion
Preparation Type: Lesion Preparations
DA-related behavior: Lesion potentiation of amphetamine induced locomotion under high stress conditions only
Gating: Medial lesions only augment PPI and lesions have no effect on LI
Citations: Miner LA, Ostrander M, Sarter M. Effects of ibotenic acid-induced loss of neurons in the medial prefrontal cortex of rats on behavioral vigilance: evidence for executive dysfunction. J Psychopharmacol . 1997 Jan 1 ; 11(2):169-78. Abstract

Wilkinson LS, Dias R, Thomas KL, Augood SJ, Everitt BJ, Robbins TW, Roberts AC. Contrasting effects of excitotoxic lesions of the prefrontal cortex on the behavioural response to D-amphetamine and presynaptic and postsynaptic measures of striatal dopamine function in monkeys. Neuroscience . 1997 Oct 1 ; 80(3):717-30. Abstract

Lipska BK, Al-Amin HA, Weinberger DR. Excitotoxic lesions of the rat medial prefrontal cortex. Effects on abnormal behaviors associated with neonatal hippocampal damage. Neuropsychopharmacology . 1998 Dec 1 ; 19(6):451-64. Abstract

Lacroix L, Spinelli S, White W, Feldon J. The effects of ibotenic acid lesions of the medial and lateral prefrontal cortex on latent inhibition, prepulse inhibition and amphetamine-induced hyperlocomotion. Neuroscience . 2000 Jan 1 ; 97(3):459-68. Abstract


October 24, 2014
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