Animal Model:	Neonatal Ventral Hippocampal Lesion
Preparation Type:	Lesion Preparations
DA-related behavior:	Enhanced locomotor responses to amphetamine with post-pubertal onset; enhanced meth-amphetamine self-administration
Gating:	Disrupted PPI; prolonged N40 latency
Cognitive behavior:	Various impairments in learning and memory (including set-shifting and spatial working memory)
Social behavior:	Impaired social behavior
Molecular/morphological signature:	Reduced presynaptic protein and growth factor expression, reduced NMDA receptor expression, impaired DA receptor expression in frontal cortex; impaired maturation of PFC; brain region- and age-specific changes in GABAA receptor expression; reduced PFC spine density; enhanced sensitivity to nicotine; increased prefrontal DA output
Response to APD:	Locomotor responses blocked by APD, social impairments blocked by clozapine but not haloperidol; clozapine reversed enhanced novelty-induced locomotor activity and rescued neuronal atrophy in the prefrontal cortex and nucleus accumbens
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