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Animal Models

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Animal Model: Type III Nrg1 Targeted Disruption, Heterozygous
Preparation Type: Genetic Preparations
Gating: PPI deficits
Cognitive behavior: Impaired short-term memory
Molecular/morphological signature: Enlarged ventricles; decreased dendritic spine density on subicular neurons
Response to APD: PPI deficits reversed by chronic nicotine treatment


May 23, 2013
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See our most recent Schizophrenia Bulletin theme Webinar: Taking Stock of Glutamate in Schizophrenia, held 5 February 2013.

Check out our Schizophrenia Bulletin theme Webinar: Neurotropic Infectious Agents and Cognitive Impairment in Schizophrenia, held 13 November 2012.
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