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Animal Model:
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STOP KO
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Hyperactive; alterations in dopaminergic neurotransmission
in the mesolimbic pathway
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Gating:
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Disrupted PPI
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Cognitive behavior:
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Deficits in short term memory and spatial learning; deficits
in long-term memory and object recognition
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Social behavior:
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Deficits in social learning and recognition
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Molecular/morphological signature:
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Enlarged ventricles; reduced volume of cortex and
diencephalon; hypoglutamatergic activity
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Response to APD:
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PPI deficit not blocked by clozapine
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Citations:
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Fradley RL, O'Meara GF, Newman RJ, Andrieux A, Job D,
Reynolds DS. STOP knockout and NMDA NR1 hypomorphic mice
exhibit deficits in sensorimotor gating. Behav Brain Res .
2005 Sep 8 ; 163(2):257-64. Abstract
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