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Animal Models

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Animal Model: STOP KO
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive; alterations in dopaminergic neurotransmission in the mesolimbic pathway
Gating: Disrupted PPI
Cognitive behavior: Deficits in short term memory and spatial learning; deficits in long-term memory and object recognition
Social behavior: Deficits in social learning and recognition
Molecular/morphological signature: Enlarged ventricles; reduced volume of cortex and diencephalon; hypoglutamatergic activity
Response to APD: PPI deficit not blocked by clozapine
Citations: Fradley RL, O'Meara GF, Newman RJ, Andrieux A, Job D, Reynolds DS. STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating. Behav Brain Res . 2005 Sep 8 ; 163(2):257-64. Abstract

Begou M, Volle J, Bertrand JB, Brun P, Job D, Schweitzer A, Saoud M, D'Amato T, Andrieux A, Suaud-Chagny MF. The stop null mice model for schizophrenia displays [corrected] cognitive and social deficits partly alleviated by neuroleptics. Neuroscience. 2008 Nov 11; 157(1):29-39. Abstract

Powell KJ, Hori SE, Leslie R, Andrieux A, Schellinck H, Thorne M, Robertson GS. Cognitive impairments in the STOP null mouse model of schizophrenia. Behav Neurosci. 2007 Oct; 121(5):826-35. Abstract

Brenner E, Sonnewald U, Schweitzer A, Andrieux A, Nehlig A. Hypoglutamatergic activity in the STOP knockout mouse: a potential model for chronic untreated schizophrenia. J Neurosci Res. 2007 Nov 15; 85(15):3487-93. Abstract

November 26, 2015
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