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Animal Models

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Animal Model: SREB2 Transgenic
Preparation Type: Genetic Preparations
Gating: PPI impairments
Cognitive behavior: Contextual memory deficits in fear-conditioning task
Social behavior: Decreased social interaction
Molecular/morphological signature: Overexpression of SREB2 (GPCR85) in forebrain; Reduced brain weight, increased ventricular volume
Citations: Matsumoto M, Straub RE, Marenco S, Nicodemus KK, Matsumoto S, Fujikawa A, Miyoshi S, Shobo M, Takahashi S, Yarimizu J, Yuri M, Hiramoto M, Morita S, Yokota H, Sasayama T, Terai K, Yoshino M, Miyake A, Callicott JH, Egan MF, Meyer-Lindenberg A, Kempf L, Honea R, Vakkalanka RK, Takasaki J, Kamohara M, Soga T, Hiyama H, Ishii H, Matsuo A, Nishimura S, Matsuoka N, Kobori M, Matsushime H, Katoh M, Furuichi K, Weinberger DR. The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia. Proc Natl Acad Sci U S A. 2008 Apr 22; 105(16):6133-8. Abstract

December 2, 2015
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