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Animal Models

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Animal Model: Selectively Bred Low PPI Wistar Rat
Preparation Type: Genetic Preparations
DA-related behavior: Reduced motivation
Gating: PPI deficits, reduced startle habituation
Cognitive behavior: Enhanced perseverative behavior
Social behavior: Decreased social interaction
Citations: Schwabe K, Freudenberg F, Koch M. Selective breeding of reduced sensorimotor gating in Wistar rats. Behav Genet. 2007 Sep; 37(5):706-12. Abstract

Dieckmann M, Freudenberg F, Klein S, Koch M, Schwabe K. Disturbed social behavior and motivation in rats selectively bred for deficient sensorimotor gating. Schizophr Res. 2007 Dec; 97(1-3):250-3. Abstract

Freudenberg F, Dieckmann M, Winter S, Koch M, Schwabe K. Selective breeding for deficient sensorimotor gating is accompanied by increased perseveration in rats. Neuroscience. 2007 Sep 7; 148(3):612-22. Abstract


December 17, 2014
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See our latest webinar, Cognition and Treatment Resistance in Schizophrenia, held November 10, 2014.

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