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product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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Proline Dehydrogenase (ProDH) KO
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Reduced open-field behavior, enhanced response to
amphetamine and MK801
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Gating:
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Diminished PPI
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Molecular/morphological signature:
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COMT, calcineurin upregulation, reduced D1 and DARPP-32
expression
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Citations:
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Gogos JA, Santha M, Takacs Z, Beck KD, Luine V, Lucas LR,
Nadler JV, Karayiorgou M. The gene encoding proline
dehydrogenase modulates sensorimotor gating in mice. Nat
Genet . 1999 Apr 1 ; 21(4):434-9. Abstract
Paterlini M, Zakharenko SS, Lai WS, Qin J, Zhang H,
Mukai J, Westphal KG, Olivier B, Sulzer D, Pavlidis P,
Siegelbaum SA, Karayiorgou M, Gogos JA. Transcriptional and
behavioral interaction between 22q11.2 orthologs modulates
schizophrenia-related phenotypes in mice. Nat Neurosci .
2005 Nov 1 ; 8(11):1586-94. Abstract
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