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Animal Models

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Animal Model: PLC-beta1 KO
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive
Gating: Sensorimotor gating deficits
Cognitive behavior: Memory impairment and lack of acquisition on hippocampal-dependent fear conditioning task
Social behavior: Abnormal social behavior
Response to APD: Clozapine (McOmish) and haloperidol (Koh) rescues sensorimotor deficits
Citations: McOmish CE, Burrows E, Howard M, Scarr E, Kim D, Shin HS, Dean B, van den Buuse M, Hannan AJ. Phospholipase C-beta1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration. Mol Psychiatry. 2008 Jul;13(7):661-72. Abstract

McOmish CE, Burrows EL, Howard M, Hannan AJ. PLC-beta1 knockout mice as a model of disrupted cortical development and plasticity: behavioral endophenotypes and dysregulation of RGS4 gene expression. Hippocampus. 2008; 18(8):824-34. Abstract

Koh HY, Kim D, Lee J, Lee S, Shin HS. Deficits in social behavior and sensorimotor gating in mice lacking phospholipase Cbeta1. Genes Brain Behav. 2008 Feb; 7(1):120-8. Abstract


November 26, 2014
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