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Animal Model:
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Phosphodiesterase 1B KO
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Enhanced behavioral response to methamphetamine
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Cognitive behavior:
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Morris water maze performance impairment
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Molecular/morphological signature:
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Increased DARPP-32 phosphorylation
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Citations:
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Reed TM, Repaske DR, Snyder GL, Greengard P, Vorhees CV.
Phosphodiesterase 1B knock-out mice exhibit exaggerated
locomotor hyperactivity and DARPP-32 phosphorylation in
response to dopamine agonists and display impaired spatial
learning. J Neurosci . 2002 Jun 15 ; 22(12):5188-97. Abstract
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