 |
|
|
Important Notice: The Forum does not endorse any medical
product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
|
Animal Model:
|
PDE4B KO
|
|
Preparation Type:
|
Genetic Preparations
|
|
DA-related behavior:
|
Reduced baseline motor activity; exaggerated locomotor
response to amphetamine
|
|
Gating:
|
Decreased PPI
|
|
Cognitive behavior:
|
No deficit in Morris water maze
|
|
Molecular/morphological signature:
|
Decreased striatal DA and 5-HT activity
|
|
Citations:
|
Siuciak JA, McCarthy SA, Chapin DS, Martin AN. Behavioral
and neurochemical characterization of mice deficient in the
phosphodiesterase-4B (PDE4B) enzyme. Psychopharmacology
(Berl) . 2008 Mar 1 ; 197(1):115-26. Abstract
|
|
|
|
|
|
Text Size 
See our most recent Schizophrenia Bulletin theme Webinar: