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Important Notice: The Forum does not endorse any medical
product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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Oxytocin and Oxytocin Receptor KO
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Preparation Type:
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Genetic Preparations
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Gating:
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PCP treatment induces large deficits in PPI
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Social behavior:
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Impaired social discrimination
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Response to APD:
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More aggressive
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Citations:
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Ferguson JN, Aldag JM, Insel TR, Young LJ. Oxytocin in the
medial amygdala is essential for social recognition in the
mouse. J Neurosci . 2001 Oct 15 ; 21(20):8278-85. Abstract
Takayanagi Y, Yoshida M, Bielsky IF, Ross HE,
Kawamata M, Onaka T, Yanagisawa T, Kimura T, Matzuk MM,
Young LJ, Nishimori K. Pervasive social deficits, but normal
parturition, in oxytocin receptor-deficient mice. Proc Natl
Acad Sci U S A . 2005 Nov 1 ; 102(44):16096-101.
Abstract
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