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Animal Models

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Animal Model: nPAS 1/3 KO
Preparation Type: Genetic Preparations
DA-related behavior: Enhanced open field locomotion
Gating: Disrupted PPI
Cognitive behavior: Decreased social recognition
Molecular/morphological signature: Reduced reelin interneurons
Citations: Erbel-Sieler C, Dudley C, Zhou Y, Wu X, Estill SJ, Han T, Diaz-Arrastia R, Brunskill EW, Potter SS, McKnight SL. Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors. Proc Natl Acad Sci U S A . 2004 Sep 14 ; 101(37):13648-53. Abstract

Pieper AA, Wu X, Han TW, Estill SJ, Dang Q, Wu LC, Reece-Fincanon S, Dudley CA, Richardson JA, Brat DJ, McKnight SL. The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice. Proc Natl Acad Sci U S A . 2005 Sep 27 ; 102(39):14052-7. Abstract

December 1, 2015
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