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Important Notice: The Forum does not endorse any medical
product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
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Animal Model:
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nPAS 1/3 KO
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Enhanced open field locomotion
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Gating:
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Disrupted PPI
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Cognitive behavior:
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Decreased social recognition
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Molecular/morphological signature:
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Reduced reelin interneurons
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Citations:
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Erbel-Sieler C, Dudley C, Zhou Y, Wu X, Estill SJ, Han T,
Diaz-Arrastia R, Brunskill EW, Potter SS, McKnight SL.
Behavioral and regulatory abnormalities in mice deficient in
the NPAS1 and NPAS3 transcription factors. Proc Natl Acad
Sci U S A . 2004 Sep 14 ; 101(37):13648-53. Abstract
Pieper AA, Wu X, Han TW, Estill SJ, Dang Q, Wu LC,
Reece-Fincanon S, Dudley CA, Richardson JA, Brat DJ,
McKnight SL. The neuronal PAS domain protein 3 transcription
factor controls FGF-mediated adult hippocampal neurogenesis
in mice. Proc Natl Acad Sci U S A . 2005 Sep 27 ;
102(39):14052-7. Abstract
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