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Animal Models

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Animal Model: NMDA NR1 Receptor Hypomorph
Preparation Type: Genetic Preparations
DA-related behavior: Enhanced response to amphetamine
Gating: Disrupted PPI
Social behavior: Impaired social interaction
Molecular/morphological signature: 95% reduction in NR1 expression
Response to APD: Behaviors improved by APD
Citations: Mohn AR, Gainetdinov RR, Caron MG, Koller BH. Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell . 1999 Aug 20 ; 98(4):427-36. Abstract

Fradley RL, O'Meara GF, Newman RJ, Andrieux A, Job D, Reynolds DS. STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating. Behav Brain Res . 2005 Sep 8 ; 163(2):257-64. Abstract


October 31, 2014
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See our upcoming webinar, Cognition and Treatment Resistance in Schizophrenia, to be held Monday, November 10, 12:00 to 1:30 p.m. EST.

See our last webinar, Research Domain Criteria (RDoC) Applied to Verbal Hallucinations, held May 28, 2014.

Check out our Schizophrenia Bulletin Forum Discussion: Prefrontal Inefficiency Is Associated With Polygenic Risk for Schizophrenia.
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