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Animal Model:
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NMDA NR1 Receptor Hypomorph
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Enhanced response to amphetamine
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Gating:
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Disrupted PPI
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Social behavior:
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Impaired social interaction
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Molecular/morphological signature:
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95% reduction in NR1 expression
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Response to APD:
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Behaviors improved by APD
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Citations:
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Mohn AR, Gainetdinov RR, Caron MG, Koller BH. Mice with
reduced NMDA receptor expression display behaviors related
to schizophrenia. Cell . 1999 Aug 20 ; 98(4):427-36. Abstract
Fradley RL, O'Meara GF, Newman RJ, Andrieux A, Job
D, Reynolds DS. STOP knockout and NMDA NR1 hypomorphic mice
exhibit deficits in sensorimotor gating. Behav Brain Res .
2005 Sep 8 ; 163(2):257-64. Abstract
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