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Animal Models

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Animal Model: NgR1 KO
Preparation Type: Genetic Preparations
DA-related behavior: Mildly hypoactive
Gating: Strain-background dependent absence of PPI
Cognitive behavior: Reduced spatial working memory
Citations: Kim JE, Liu BP, Park JH, Strittmatter SM. Nogo-66 receptor prevents raphespinal and rubrospinal axon regeneration and limits functional recovery from spinal cord injury. Neuron. 2004 Oct 28; 44(3):439-51. Abstract

Budel S, Padukkavidana T, Liu BP, Feng Z, Hu F, Johnson S, Lauren J, Park JH, McGee AW, Liao J, Stillman A, Kim JE, Yang BZ, Sodi S, Gelernter J, Zhao H, Hisama F, Arnsten AF, Strittmatter SM. Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth. J Neurosci. 2008 Dec 3; 28(49):13161-72. Abstract

October 9, 2015
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