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Animal Models

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Animal Model: Neuregulin 1 Hypomorph (Transmembrane Domain)
Preparation Type: Genetic Preparations
DA-related behavior: Hyperactive in open field test
Gating: Disrupted PPI
Cognitive behavior: No impairment in spatial learning or working memory but diminished social recognition memory
Social behavior: Increase in dominance related and aggressive behavior depending on environment
Molecular/morphological signature: Reduced NMDA receptor activity; increased serotonin 2A receptors and serotonin transporters in CNS
Response to APD: Open field behavior reversed by clozapine but not PPI
Citations: Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, Brynjolfsson J, Gunnarsdottir S, Ivarsson O, Chou TT, Hjaltason O, Birgisdottir B, Jonsson H, Gudnadottir VG, Gudmundsdottir E, Bjornsson A, Ingvarsson B, Ingason A, Sigfusson S, Hardardottir H, Harvey RP, Lai D, Zhou M, Brunner D, Mutel V, Gonzalo A, Lemke G, Sainz J, Johannesson G, Andresson T, Gudbjartsson D, Manolescu A, Frigge ML, Gurney ME, Kong A, Gulcher JR, Petursson H, Stefansson K. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet . 2002 Oct 1 ; 71(4):877-92. Abstract


October 22, 2014
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