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Animal Model:
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mGluR5 Knockout
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Preparation Type:
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Genetic Preparations
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DA-related behavior:
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Abnormal locomotor patterns; increased sensitivity to
hyperlocomotive effects of MK-801
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Gating:
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Disrupted PPI
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Cognitive behavior:
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Short term spatial memory deficits
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Response to APD:
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APD not effective; clozapine reversed PPI deficit and
ameliorated locomotor disruption (Gray)
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Citations:
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Kinney GG, Burno M, Campbell UC, Hernandez LM, Rodriguez D,
Bristow LJ, Conn PJ. Metabotropic glutamate subtype 5
receptors modulate locomotor activity and sensorimotor
gating in rodents. J Pharmacol Exp Ther . 2003 Jul 1 ;
306(1):116-23. Abstract
Brody SA, Dulawa SC, Conquet F, Geyer MA. Assessment
of a prepulse inhibition deficit in a mutant mouse lacking
mGlu5 receptors. Mol Psychiatry . 2004 Jan 1 ; 9(1):35-41.
Abstract
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