 |
|
|
Important Notice: The Forum does not endorse any medical
product or therapy. ALL medications and supplements
should be taken ONLY under the supervision of a physician,
due to the possibility of side-effects, drug interactions,
etc.
|
Animal Model:
|
Glycine Transporter KO
|
|
Preparation Type:
|
Genetic Preparations
|
|
DA-related behavior:
|
Locomotor response to psycho-stimulants same as wild-type
|
|
Gating:
|
Reduced sensitivity to amphetamine to disrupt PPI but more
MK-801 induced disruption
|
|
Cognitive behavior:
|
Improves memory retention
|
|
Molecular/morphological signature:
|
Increased NMDA receptor expression and function
|
|
Citations:
|
Tsai G, Ralph-Williams RJ, Martina M, Bergeron R,
Berger-Sweeney J, Dunham KS, Jiang Z, Caine SB, Coyle JT.
Gene knockout of glycine transporter 1: characterization of
the behavioral phenotype. Proc Natl Acad Sci U S A . 2004
Jun 1 ; 101(22):8485-90. Abstract
|
|
|
|
|
|
Text Size 
See our most recent Schizophrenia Bulletin theme Webinar: